Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression.
نویسندگان
چکیده
The aim of our study was to investigate the level of metabotropic glutamate receptors (mGluRs) in the brains of rats after chronic mild stress. Using Western blotting procedure we showed that the level of mGluR5 receptor protein was increased in CA1 and decreased in CA3 region of the hippocampus. Our results indicate that mGluR5 can possibly be engaged in the mechanism of depression.
منابع مشابه
PRELIMINARY COMMUNICATION CHANGES IN THE EXPRESSION OF METABOTROPIC GLUTAMATE RECEPTOR 5 (mGluR5) IN THE RAT HIPPOCAMPUS IN AN ANIMAL MODEL OF DEPRESSION
Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression. The aim of our study was to investigate the level of metabotropic glutamate receptors (mGluRs) in the brains of rats after chronic mild stress. Using Western blotting procedure we showed that the level of mGluR5 receptor protein was increased in CA1 and decreased in C...
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عنوان ژورنال:
- Polish journal of pharmacology
دوره 53 6 شماره
صفحات -
تاریخ انتشار 2001